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Rotating the injection site with each dose helps minimize the risk of injection-related side effects

Patients who may not be appropriate candidates include: Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Those with a history of severe hypersensitivity reactions to semaglutide Patients with a history of pancreatitis (relative contraindication requiring careful risk-benefit assessment) Pregnant women or those planning pregnancy (contraindicated for weight management

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The FDA has approved Qsymia (phentermine and topiramate) in children aged 12 years and older whose BMI is at the 95th percentile or higher, standardized for age and gender

These agents effectively improved glucose and lipid metabolism in clinical trials 12,13